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KMID : 0928520060160020281
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Korean Journal of Lipidology
2006 Volume.16 No. 2 p.281 ~ p.288
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Increased Serum Ferritin Concentration is Associated with Increased Arterial Stiffness Assessed by Pulse Wave Velocity
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Lee Min-Su
Park Hyeong-Seo
Park Jae-Hyeong
Lee Jae-Hwan
Ku Bon-Jeong
Kim Dae-Hyun
Kim Jei
Lee Tae-Yong
Seong In-Whan
Jung Jin-Ok
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Abstract
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Objective: Increased serum ferritin concentration can be associated with elevated oxidative stress and the development of arteriosclerosis. We evaluated the relationship between increased ferritin level and arterial stiffness in a normal population without known coronary and cerebrovascular diseases.
Methods: We evaluated a total of 995 subjects (578 females; mean age: 58±8 years). After excluding subjects with known cardiovascular and cerebrovascular disease, we analyzed data from 949 subjects. Risk factors of coronary arterial disease (CAD), serum cholesterol profiles, high-sensitive C-reactive protein, fasting blood sugar (FBS) level, and ferritin concentrations were recorded. Arterial stiffness was assessed by brachial to ankle pulse-wave velocity (baPWV).
Results: A univariate analysis revealed the following: baPWV was correlated with conventional clinical variables, including age (R=0.389, P<0.001), sex (R=0.099, P=0.002), blood pressure (systolic (R=0.614, P<0.001), diastolic (R=0.417, P<0.001)), triglyceride concentration (R=0.151, P<0.001), and FBS level (R=0.184, P<0.001). The baPWV was also correlated with the 10-year cardiovascular risk score (R=0.419, P<0.001) and serum ferritin concentration (R=0.184, P<0.001). The multivariate analysis demonstrated that baPWV was significantly correlated with serum ferritin concentration; this was similar to other cardiovascular risk factors, including age, blood pressure, smoking, and FBS concentration.
Conclusion: Elevated serum ferritin concentration was associated with increased arterial stiffness in subjects without known coronary and cerebrovascular diseases; this may contribute to increased cardiovascular risk.
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KEYWORD
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Arteriosclerosis, Ferritin, Arterial stiffness
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